Colostrums Immunoglobulin Potential Effects Against Some Biochemical Changes In Diabetic Rats

Diabetes mellitus is one of the most distributed public health problem which increases the ability of other diseases and risks. The present work was concerned with the investigation of colostrum immunoglobulin potential effects on some biochemical changes in diabetic rats. The results showed the impact of oral administration of colostrum in healthy and diabetic rats. Regarding to fecal characteristics reflected the improvement of gastrointestinal tract function as increase the absorption which result in decrease fecal weights in association with minimized its volume that significantly effect on the fecal density with slightly increased in pH mean value in case of consuming colostrum. Hematological measurements reflected the positive effects of consuming colostrum on RBCs, WBCs counts, hemoglobin concentration and hematocrit values; as well as erythrocytes indices; such as erythrocyte size or hemoglobin contents. The biochemical measurements showed an improvement in insulin level as well as plasma glucose level in colostrum consumed group. The decrement was reach 21.94% in diabetic rats group compared with healthy group consumed water. On the other hand there were highly significant increases in serum total proteins, albumin and globulin which affect A/G ratio in both healthy and diabetic rat groups. When diabetic rats consumed colostrum it resulted in significant reduction in lipids pattern, the decrement reached 29.53%, 6.90%, 25.09 % and 17.39% for total lipids, total cholesterol, triacylglycerol, and LDL-c, respectively in association with the increase in the percentage of HDL-c by 57.99% compared to their corresponding control group that drank water. Data showed that colostrum has positive effect on reducing the oxidative stress risk accompanied with diabetes mellitus including decreased plasma malondialdehyde level with increase in both erythrocytes SOD enzyme activity and increase in hepatic reduced glutathione level. Positive immunological responses were also observed in the levels of immunoglobulin classes IgG and IgA when healthy or diabetic rats received colostrum.